Endocrine Abstracts

Introduction: The prevalence of non-communicable disorders such as metabolic syndrome (MetS) is high in developing countries. MetS is a disorder of energy utilisation and storage, diagnosed by a co-occurrence of three out of five of the following medical conditions: abdominal (central) obesity, elevated blood pressure, elevated fasting plasma glucose, high serum triglycerides, and low HDL cholesterol levels. The present review aims to discover the genetic variant reported in a...

Introduction: Thyroid cancer is the most common endocrine cancer and medullary thyroid carcinoma (MTC) is one of the most malignant thyroid tumours which occur in both hereditary (25%) and sporadic (75%) forms. Mutations of the RET proto-oncogene in MTC development have been well demonstrated. The aim of the study was to investigate the mutational spectrum of exons 3, 5, 8, and 10–18 of RET proto-oncogene in MTC patients.Material and methods: This r...

Introduction: Thyroid cancer is the most common endocrine cancer and medullary thyroid carcinoma (MTC) is one of the most malignant thyroid tumours which occur in both hereditary (25%) and sporadic (75%) forms. Mutations of the RET proto-oncogene in MTC development have been well demonstrated. The aim of the study was to investigate the mutational spectrum of exons 3, 5, 8, and 10–18 of RET proto-oncogene in MTC patients.Material and methods: This r...

Background: Integration between fat tissue, gastrointestinal tract, and the brain has attracted scientific interest in recent years. Thyroid hormones influence carbohydrate mechanisms via its interaction with adipocytokines and gut hormones. Adiponectin, ghrelin and obestatin play important roles in metabolism regulation. TSH receptors have been reported to be present in adipose tissue. Moreover, gut peptides signal to their functional cogna...

Objective: The aim of this study was the assessment of association of two single nucleotide polymorphism (SNP) of thyroid peroxidase (TPO) gene with anti TPO antibody titer for the first time.Materials and methods: In this case–control study, peripheral blood samples of 428 individuals, 178 men (29–76 y) and 250 women (21–76 y) from unrelated families were genotyped (G1201T of exon 8 and A2257C of exon 12) by PCR amplification and RLFP met...

Introduction: High sensitive CRP (hsCRP) has been reported to associate with an increased risk of cardiovascular disease. There is some evidence on apoE polymorphism in relation to the parameters of inflammation. We have investigated the association between APOE genotypes and hsCRP levels in an Iranian population.Materials and methods: We performed a cross-sectional study of 966 subjects (419 men and 547 women) from the Tehran Lipid and Glucose Study. hs...

Introduction: Leptin is a well-known adipokine which has a critical role in the regulation of body weight, body fat mass, appetite, and food intakes. Energy-supplying nutrients such as carbohydrates is a dietary-related factor which has potential effects on plasma leptin levels. The effect of habitual carbohydrates intake on leptin gene expression was limited only in animal studies. The current study aimed to investigate the association of habitual carbohydrate intake with lep...

Background and aim: Apelin, as an adipokine, is encoded by the APLN gene. It is a key regulator in glucose and lipid metabolism and plays an important role in the pathogenesis of insulin resistance and type 2 diabetes. It seems that habitual dietary intake of carbohydrates including quality and quantity by chronic manipulating insulin concentration might have a distinguishing role in the prediction of apelin gene expression in adipose tissue, but there is no evidence in this r...

Introduction: Human fat mass and obesity-associated gene (FTO) gene expression are associated with body mass index and type 2 diabetes. It is unknown whether lifestyle factors, such as physical activity, can attenuate weight gain and obesity by contribution to the FTO gene regulation. The objective of the present study was to investigate the association between habitual physical activity and the FTO gene expression among morbid obese and non-obese subjects.<p class="abstex...

New evidence indicated that miRNAs may contribute to the regulation of energy balance and metabolic homeostasis, by controlling a wide range of metabolic pathways. miR-143 and miR-34a are the best studied among the miRNAs linked to adipose tissue regulation. Dietary intake, among many other environmental factors, is a key player that can induce epigenetic changes. The aim of the study was to investigate the association of the miR-143 and miR-34a expression in visceral and subc...